DSpace Community: Pathology

Surgical asepsis

2021-10-20T10:49:50Z

Title: Surgical asepsis Authors: Eyarefe, O. D. Description: In: A. Adetunji, Essential Veterinary Surgery, Ibadan: Ibadan University Press, 2014. Pp. 197 - 210

Splenic lymphoma in an adult local bitch: a case report

2021-10-20T10:45:36Z

Title: Splenic lymphoma in an adult local bitch: a case report Authors: Oni, S. O.; Akinrinmade, J. F.; Ajadi, R. A.; Eyarefe, O. D.; Olaifa, A. K. Abstract: A four-year old local dog weighing 12kg was presented four days after signs of persistent anorexia and dullness were observed. Physical examination of the bitch revealed a circumscribed distension of the left lateral abdomen about 5cm caudal to the rib cage, which on palpation appeared firm, discrete and nodular but painless. X-rays views confirmed that the mass was intrasplenic and had a fat density. Blood and urine samples were analysed, the result of which showed proteinuria, bilirubinuria and neutrophilic leucocyosis. Exploratory laparotomy and spleenectomy were carried out. The extirpated spleen had pendunculated projection. The biopsy of the spleen revealed that the tumour is a lymphoma

Small bowel responses to enteral honey and glutamine administration following massive small bowel resection in rabbit

2021-10-20T08:48:04Z

Title: Small bowel responses to enteral honey and glutamine administration following massive small bowel resection in rabbit Authors: Evarefe, O.D.; Emikpe, B.O.; Arowolo, R. O. A. Abstract: The trophic effects of honey and glutamine in the healing and adaptation of the small bowel following intestinal resection were studied in some Nigerian non-descript breeds of rabbits. Nine rabbits of mixed sexes with mean body weight of 1.45 ±0.55kg were used. They were randomised into three treatment groups following 50% small bowel resection. Group A rabbits were placed on oral honey treatment. Group B on oral glutamine and group C on normal saline (control). All groups exhibited signs of small bowel adaptation (glutamine(B) honey (A) control (C) at the end of the experiment (4 weeks) with oral glutamine showing the best overall effects on intestinal mucosal growth and adaptation evidenced by significant increase (P<0.05) in residual bow'el length (37.3%), villi width (20.0%), crypt depth (113.3%) and a non significant increase in villus height (33.3%) and cellular mass (10.2%). Honey showed a better effect than control with a significant increase (P<0.05) in villi width (18.2%), crypts depth (66.7%) and cellular mass (33.9%) and a non significant increase in gross residual bow'el length (24.6%), and villus height (30.5%). Our result shows that honey and glutamine have trophic effects on bowel mucosa healing and hyperplasia and have potential therapeutic effects on massive bowel resection in humans

Small bowel wall response to enterotomy closure with polypropylene and polyglactin 910 using simple interrupted suture pattern in rats

2021-10-20T08:35:04Z

Title: Small bowel wall response to enterotomy closure with polypropylene and polyglactin 910 using simple interrupted suture pattern in rats Authors: Eyarefe, O.D.; Amid, S.A. Abstract: Effects of polypropylene and polyglactin 910 on enterotomy wound healing were investigated. Sixteen adult W istar albino rats (155.44±30.4 g) w ere randomized into two study groups, A with polypropylene (n = 8) and B with polyglactin 910 (n = 8) following 1 cm mid-jejunal enterotomy incisions performed under ketamine/xylazine anaesthesia. Body weights changes were evaluated daily for eleven days and two rats from each group were euthanized at postoperative days 3, 5, 7 and 11. Following euthanasia, the enterotomy sites were examined for dehiscence and adhesion. Evidence of inflammatory reactions and fibroblast proliferation were also evaluated and scored. Leaks from enterotomy site were not observed. Adhesion scores in-group A(3.5) was statistically significant (p<0.05) when compared with group B (1.875). A non-statistically significant (p>0.05) but higher fibroblasts count was recorded in Group A (2.625) compared with group B (1.375). Inflammatory responses in both groups were not statistically significant, although that of Group B was higher in response than group A. Enterotomy closure with polypropylene produced significant adhesion that may be linked with the texture of the suture, and the several knots characteristic of the simple interrupted suture pattern