Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorOla, S. O.-
dc.contributor.authorOtegbayo, J. A.-
dc.contributor.authorOdaibo, G. N.-
dc.contributor.authorOlaleye, D. O.-
dc.contributor.authorSummerton, C. B.-
dc.contributor.authorBamgboye, E. A.-
dc.identifier.otherJournal of Infection in developing Countries 3(6), pp. 442-446-
dc.description.abstract"OBJECTIVE:To determine markers of HBV infection and detect the presence of its occult infection in serum of a cohort of adult Nigerians. METHODOLOGY:The study involved 28 adult Nigerians with viral hepatitis (Group 1) and 28 apparently healthy adult Nigerians as controls (Group 2). Their sera were assayed for HBsAg, HBeAg, anti-HBe, anti-HBc, anti-HBs, and anti-HCV, while HBV DNA was determined in 15 patients with chronic hepatitis. Significance of differences between the patients and control subjects was assessed using Chi-square test at a 95% confidence level. RESULTS:Sero-detection of HBsAg, HBeAg, anti-HBe and anti-HBc was higher among the patients compared to the controls. HBV infection was diagnosed by HBsAg (89%) and a duo of HBsAg and anti-HBc (100%) among the patients. Similarly, eleven and four types of different patterns of HBV markers were observed among the respective groups. Anti-HBe (9.5%), anti-HBc (14.3%), and anti-HBs (9.5%) were detected among all the subjects who were sero-negative for HBsAg. HBV DNA was also detected in 86.7% of the 15 patients with chronic hepatitis, while occult HBV infection was observed in 7.2% of the patients and none (0%) of the controls, p < 0.05. Furthermore, HCV infection occurred among subjects with all the different patterns of HBV markers, except those with occult HBV infection and natural immunity to HBV. CONCLUSION:This study shows that occult HBV infection is present among Nigerian adults and determination of HBsAg, anti-HBc, anti-HBe, and HBV DNA will assist in its detection."en_US
dc.publisherCreative Commons Attibutionen_US
dc.subjectoccult HBV infection,en_US
dc.titleOccult HBV infection among a cohort of Nigerian adultsen_US
Appears in Collections:scholarly works

Files in This Item:
File Description SizeFormat 
(40)ui_art_ola_occult_2009.pdf498.6 kBAdobe PDFThumbnail

Items in UISpace are protected by copyright, with all rights reserved, unless otherwise indicated.